Targeting Trafficking in Drug Development

Description

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding. Front Matter ....Pages i-viii Intracellular Trafficking of Gonadotropin Receptors in Health and Disease (Alfredo Ulloa-Aguirre, Teresa Zariñán, Rubén Gutiérrez-Sagal, James A. Dias)....Pages 1-39 Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches (Simon R. Foster, Hans Bräuner-Osborne)....Pages 41-61 Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors (Bernard Mouillac, Christiane Mendre)....Pages 63-83 Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases (Francesca Longhena, PierFranco Spano, Arianna Bellucci)....Pages 85-110 Pharmacoperones for Misfolded Gonadotropin Receptors (Claire L. Newton, Ross C. Anderson)....Pages 111-134 Pharmacological Chaperones: Beyond Conformational Disorders (Nancy J. Leidenheimer)....Pages 135-153 Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer (Isabel Betancor-Fernández, David J. Timson, Eduardo Salido, Angel L. Pey)....Pages 155-190 Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches (Meritxell B. Cutrona, Niamh E. Morgan, Jeremy C. Simpson)....Pages 191-225 Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking (Leslie K. Climer, Rachel D. Hendrix, Vladimir V. Lupashin)....Pages 227-247 SLC6 Transporter Folding Diseases and Pharmacochaperoning (Michael Freissmuth, Thomas Stockner, Sonja Sucic)....Pages 249-270 The Molecular Physiopathogenesis of Islet Amyloidosis (Diti Chatterjee Bhowmick, Sanghamitra Singh, Saurabh Trikha, Aleksandar M. Jeremic)....Pages 271-312 Folding Defects Leading to Primary Hyperoxaluria (Elisa Oppici, Mirco Dindo, Carolina Conter, Carla Borri Voltattorni, Barbara Cellini)....Pages 313-343 Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria (Tomas Majtan, Angel L. Pey, Paula Gimenez-Mascarell, Luis Alfonso Martínez-Cruz, Csaba Szabo, Viktor Kožich et al.)....Pages 345-383 Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator and Drugs: Insights from Cellular Trafficking (Robert J. Bridges, Neil A. Bradbury)....Pages 385-425