Molecular Toxicology in Caenorhabditis elegans

Description

This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans. Front Matter ....Pages i-xviii Molecular Basis for Oxidative Stress Induced by Environmental Toxicants in Nematodes (Dayong Wang)....Pages 1-30 Molecular Basis for Reduced Lifespan Induced by Environmental Toxicants or Stresses (Dayong Wang)....Pages 31-58 Roles of Oxidative Stress-Related Molecular Signals in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 59-88 Functions of MAPK Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 89-115 Functions of Insulin and the Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 117-146 Functions of Development-Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 147-179 Functions of Cell Death and DNA Damage-Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 181-201 Functions of Metabolism-Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 203-229 Functions of Protective Response-Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 231-292 Functions of G-Protein-Coupled Receptors and Ion Channels and the Downstream Cytoplasmic Signals in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 293-326 Discussion on Specificity of Molecular Signals in Response to Certain Environmental Toxicants or Stresses (Dayong Wang)....Pages 327-349 Epigenetic Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 351-390 Strategies to Screen and to Identify New Genetic Loci Involved in the Regulation of Toxicity of Environmental Toxicants or Stresses (Dayong Wang)....Pages 391-409 Molecular Basis for Adaptive Response to Environmental Toxicants or Stresses (Dayong Wang)....Pages 411-428 Molecular Basis for Transgenerational Toxicity Induction of Environmental Toxicants or Stresses (Dayong Wang)....Pages 429-447