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Current Topics in Cellular Regulation, Volume 1 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including the transfer of genetic information, intermediary metabolism, and cellular differentiation. This book discusses the advances in the general area of cellular regulation. Organized into 10 chapters, this volume begins with an overview of the molecular models that attempt to provide the correlation of the kinetic properties of the protein with its structural architecture. This text then examines several aspects of metabolism and of metabolic enzymes that appear to represent adaptations to the need to limit solute concentrations and conserve solvent capacity. Other chapters consider the factors that determine the overall rates of metabolic pathways. This book discusses as well the biosynthetic pathways leading to the branched-chain amino acids. The final chapter deals with the structure and mechanism of action of pyruvate carboxylase. This book is a valuable resource for biologists and biochemists. Content: Contributors to Volume 1Page ii Front MatterPage iii Copyright pagePage iv List of ContributorsPage v PrefacePage viiBERNARD L. HORECKER, EARL R. STADTMAN Conformational Aspects of Enzyme RegulationPages 1-27D.E. KOSHLAND JR. Limitation of Metabolite Concentrations and the Conservation of Solvent Capacity in the Living CellPages 29-43DANIEL E. ATKINSON The Role of Equilibria in the Regulation of MetabolismPages 45-55H.A. KREBS Regulation of the Biosynthesis of the Branched-Chain Amino AcidsPages 57-76H.E. UMBARGER On the Roles of Synthesis and Degradation in Regulation of Enzyme Levels in Mammalian Tissues*Pages 77-124ROBERT T. SCHIMKE The Regulation of the Biosynthesis of α-1,4 Glucans in Bacteria and PlantsPages 125-160JACK PREISS Allosteric L-Threonine Dehydrases of MicroorganismsPages 161-182W.A. WOOD The Aspartokinases and Homoserine Dehydrogenases of Escherichia coliPages 183-231GEORGES N. COHEN Pyruvate Dehydrogenase ComplexPages 233-251LESTER J. REED Pyruvate Carboxylase*Pages 253-296MERTON F. UTTER, MICHAEL C. SCRUTTON Author IndexPages 297-310 Subject IndexPages 311-314