Organofluorine Chemistry

Description

The replacement of hydrogen with fluorine in organic molecules can profoundly influence their chemical and physical properties, leading to a range of compounds with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, so that organofluorine chemistry is economically highly important. Organofluorine Chemistry will help chemists to develop a systematic knowledge of the chemistry of fluorine with a view towards its application in the design of new reactions and syntheses, and the creation of novel fluorinated molecules and materials. With initial chapters focusing on why fluorine creates such unique properties in organic compounds, the book then covers general reactions of fluorine. Coverage is chosen from the recent research literature, concentrating on the development of novel bioactive compounds and catalytic ligands, and explaining, in the context of the initial chapters, how and why fluorine is so effective. With a final chapter covering the general synthetic chemistry of organofluorine compounds, the book is a cohesive summary of the fundamental principals of organofluorine chemistry.Content: Chapter 1 Fundamentals in Organic Fluorine Chemistry (pages 1–100): Chapter 2 Unique Reactions Incluced by Fluorine (pages 101–138): Chapter 3 Reactions Activated by a Strong Interaction Between Fluorine and Other Atoms (pages 139–172): Chapter 4 Hydrogen Bonding in Organofluorine Compounds (pages 173–185): Chapter 5 Fluorinated Ligands for Selective Catalytic Reactions (pages 186–205): Chapter 6 Fluorine in Drug Designs (pages 206–222): Chapter 7 Method for Introduction of Fluorine?Functionality Into Molecules (pages 223–336):