ENGLISH

Molecular and Cellular Therapies for Motor Neuron Diseases

By Nicholas M. Boulis , Deirdre O'Connor and Anthony Donsante (Eds.)

Book information

Publisher
Academic Press
Year
2017
ISBN
9780128025246, 9780128022573
Language
english
Format
PDF
Filesize
12 MB (12957154 bytes)
Edition
1st Edition
Pages
336 \318
Time added
2017-08-08 21:00:00
Home;Books & Journals;Neuroscience;Cellular and Mo

Description

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Content: Front-matter,Copyright,List of Contributors,AcknowledgmentEntitled to full textChapter 1 - Molecular and Extracellular Cues in Motor Neuron Specification and Differentiation, Pages 1-24, R.L. Swetenburg, S.L. Stice, L. Karumbaiah Chapter 2 - Natural History of Amyotrophic Lateral Sclerosis, Pages 25-41, M.J. Magnussen, J.D. Glass Chapter 3 - Genetics of Amyotrophic Lateral Sclerosis, Pages 43-59, K.P. Kenna, J.E. Landers, N. Ticozzi Chapter 4 - Molecular Mechanisms of Amyotrophic Lateral Sclerosis, Pages 61-99, M. Collins, R. Bowser Chapter 5 - An Introduction to the Natural History, Genetic Mapping, and Clinical Spectrum of Spinal Muscular Atrophy, Pages 101-120, A. McDonough, L. Urquia, N. Boulis Chapter 6 - Genetics of Spinal Muscular Atrophy, Pages 121-139, A.H.M. Burghes, V.L. McGovern Chapter 7 - Introduction to Gene and Stem-Cell Therapy, Pages 141-165, D.M. O'Connor Chapter 8 - Gene Therapy for Amyotrophic Lateral Sclerosis: Therapeutic Transgenes, Pages 167-205, A. Donsante Chapter 9 - Stem Cell Therapy for Amyotrophic Lateral Sclerosis, Pages 207-231, K.S. Chen, E.L. Feldman Chapter 10 - Gene Therapy for Spinal Muscular Atrophy, Pages 233-250, M.R. Miller, E.Y. Osman, C.L. Lorson Chapter 11 - Cellular Therapy for Spinal Muscular Atrophy: Pearls and Pitfalls, Pages 251-275, I. Faravelli, S. Corti Chapter 12 - Clinical Trials to Date, Pages 277-308, B.J. Mader, N. Boulis Index, Pages 309-321

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