Parkinson's Disease. Molecular Mechanisms Underlying Pathology
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Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes.Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Content: Front matter,Copyright,List of Contributors,PrefaceEntitled to full textChapter 1 - The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders, Pages 1-40, C.M. Lill, C. Klein Chapter 2 - Electron Transport Chain, Pages 41-75, L. Aerts, V.A. Morais Chapter 3 - Mitochondrial Fission and Fusion, Pages 77-111, V.L. Hewitt, A.J. Whitworth Chapter 4 - Axonal Mitochondrial Transport, Pages 113-137, E. Shlevkov, T.L. Schwarz Chapter 5 - Mitophagy, Pages 139-177, L. King, H. Plun-Favreau Chapter 6 - Autophagy, Pages 179-206, P.A. Lewis, M. Perez-Carrion, G. Piccoli Chapter 7 - Endocytosis and Synaptic Function, Pages 207-243, S.F. Soukup, P. Verstreken, S. Vilain Chapter 8 - Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease, Pages 245-279, C. Cebrián, D. Sulzer Chapter 9 - Protein Translation in Parkinson’s Disease, Pages 281-309, J.W. Kim, L. Abalde-Atristain, H. Jia, I. Martin, T.M. Dawson, V.L. Dawson Index, Pages 311-318
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