Disruption of Protein-Protein Interfaces: In Search of New Inhibitors

Description

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces. Front Matter....Pages i-vii Drug Discovery by Targeting Protein–Protein Interactions....Pages 1-29 Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds....Pages 31-60 Disrupting Protein–Protein Interfaces Using GRID Molecular Interaction Fields....Pages 61-82 NMR as a Tool to Target Protein–Protein Interactions....Pages 83-111 Protein–Protein Interactions in the Solid State: The Troubles of Crystallizing Protein–Protein Complexes....Pages 113-134 Fluorescence Observables and Enzyme Kinetics in the Investigation of PPI Modulation by Small Molecules: Detection, Mechanistic Insight, and Functional Consequences....Pages 135-158 Back Matter....Pages 159-161