The Way of Synthesis: Evolution of Design and Methods for Natural Products

Description

This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. INTRODUCTION The History of Synthesis Milestones in Organic Sythesis STRATEGY AND TACTICS Principles and Issues Impacting Synthesis (Strategy) Principles and Issues Impacting Design (Strategy) Principles and Issues of Methods (Tactics) COMPARATIVE DESIGN: CLASSICS IN TERPENE SYNTHESIS Juvenile Hormones Cedrenes Zizaanes Hydroazulenes Vernolepin Triquinanes Compactin Aphidicolin Miscellaneous Diterpenes Taxol COMPARATIVE DESIGN: CLASSICS IN ALKALOID SYNTHESIS Lycopodium Alkaloids Daphniphyllum Alkaloids, Daphnilactone A Pyrrolizidine Alkaloids Amaryllidaceae Alkaloids Morphine Indole Alkaloids MISCELLANEOUS SYNTHESES Maytansine Palytoxin Brevetoxin B Indinavir OUTLOOK