Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles: Application to Drug Delivery System

Description

Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow. PRELIMS.pdf Preface Acknowledgements Author biographies Huilin Ye Zhiqiang Shen Ying Li Symbols CH001.pdf Chapter 1 Background 1.1 Blood flow in human vasculature 1.2 Vascular targeting and margination of particles in blood flow 1.3 Adhesion of particles on endothelium wall References CH002.pdf Chapter 2 Numerical methods: fluid–structure interaction and adhesive dynamics 2.1 Fluid–structure interaction 2.1.1 Plasma dynamics: lattice Boltzmann method 2.1.2 Coarse-grained model for blood cells and particles 2.1.3 Immersed boundary method 2.2 Adhesive dynamics 2.3 Validation of numerical method 2.3.1 Validation of red blood cell model 2.3.2 Validation of red blood cell suspension References CH003.pdf Chapter 3 Anomalous vascular dynamics of nanoworms within blood flow 3.1 Motivation 3.2 Experimental and computational results 3.2.1 Experiment 3.2.2 Computational results References CH004.pdf Chapter 4 Adhesion behavior of a single cell on the endothelial wall 4.1 Introduction 4.2 Computational model 4.3 Results and discussion 4.3.1 Four types of motion and demargination 4.3.2 Effect of particle stiffness on the formation of bonds and adhesive force 4.3.3 Phase diagram and scaling relationship References CH005.pdf Chapter 5 Localization of soft particles: margination and adhesion 5.1 Introduction 5.2 Physical problem and computational method 5.2.1 Physical problem 5.3 Results and discussion 5.3.1 Margination of elastic MPs without adhesion 5.3.2 Adhesion effect on localization of elastic MPs at the wall 5.3.3 Adhesion behavior of elastic MPs 5.3.4 Mechanism of localization of elastic MPs under adhesion References CH006.pdf Chapter 6 Shape-dependent transport of micro-particles in blood flow: from margination to adhesion 6.1 Introduction 6.2 Computational model setup 6.3 Results and discussion 6.3.1 Margination of MPs without adhesion 6.3.2 Margination of MPs with adhesion 6.3.3 Mechanism of adhesion effect on margination behavior References CH007.pdf Chapter 7 Conclusion and perspective References APP1.pdf Chapter