Laser Interaction with Heterogeneous Biological Tissue

Description

This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin. In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells. Front Matter ....Pages i-xii Methods Describing the Interaction of Laser Radiation with Biological Tissues (Kirill Kulikov, Tatiana Koshlan)....Pages 1-8 Overview of Theoretical Approaches to the Analysis of Light Scattering (Kirill Kulikov, Tatiana Koshlan)....Pages 9-25 Study of Electrophysical Characteristics of Blood Formed Elements Using Intracavity Laser Spectroscopy (Kirill Kulikov, Tatiana Koshlan)....Pages 27-65 Mathematical Models of the Interaction of Laser Radiation with Turbid Media (Kirill Kulikov, Tatiana Koshlan)....Pages 67-88 Study of the Optical Characteristics of a Biotissue with Large-Scale Inhomogeneities (Kirill Kulikov, Tatiana Koshlan)....Pages 89-102 Light Scattering by Dielectric Bodies of Irregular Shape in a Layered Medium (Kirill Kulikov, Tatiana Koshlan)....Pages 103-130 Modeling of the Optical Characteristics Fibrillar Structure (Kirill Kulikov, Tatiana Koshlan)....Pages 131-143 Theoretical Determination the Function of Size Distribution for Blood Cells (Kirill Kulikov, Tatiana Koshlan)....Pages 145-152 Study of Optical Properties of Biotissues by the Intracavity Laser Spectroscopy Method (Kirill Kulikov, Tatiana Koshlan)....Pages 153-159 Study of the Optical Characteristics of Thin Layer of the Biological Sample (Kirill Kulikov, Tatiana Koshlan)....Pages 161-170 Simulation of the Thermal Processes (Kirill Kulikov, Tatiana Koshlan)....Pages 171-178 Determination of the Optical Parameters on the Basis of Spectrophotometric Data (Kirill Kulikov, Tatiana Koshlan)....Pages 179-186 Back Matter ....Pages 187-189