Genetic Epidemiology

Description

This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls. Front Matter ....Pages i-x Introduction to Epidemiological Studies (Lazaros Belbasis, Vanesa Bellou)....Pages 1-6 Key Concepts in Genetic Epidemiology (Kalliope Panoutsopoulou, Eleanor Wheeler)....Pages 7-24 Quality Control of Common and Rare Variants (Kalliope Panoutsopoulou, Klaudia Walter)....Pages 25-36 Genome-Wide Association Studies (Abbas Dehghan)....Pages 37-49 Assessing Rare Variation in Complex Traits (Karoline Kuchenbaecker, Emil Vincent Rosenbaum Appel)....Pages 51-71 Meta-Analysis of Common and Rare Variants (Kyriaki Michailidou)....Pages 73-88 Gene-Gene and Gene-Environment Interactions (Andrew T. DeWan)....Pages 89-110 Genetic Association in the HLA Region (Loukas Moutsianas, Javier Gutierrez-Achury)....Pages 111-134 Novel Methods for Family-Based Genetic Studies (Qi Yan)....Pages 135-144 Methods for Polygenic Traits (Raha Pazoki)....Pages 145-156 Multivariate Methods for Meta-Analysis of Genetic Association Studies (Niki L. Dimou, Katerina G. Pantavou, Georgia G. Braliou, Pantelis G. Bagos)....Pages 157-182 Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes (Panagiota I Kontou, Athanasia Pavlopoulou, Pantelis G. Bagos)....Pages 183-210 A Primer in Mendelian Randomization Methodology with a Focus on Utilizing Published Summary Association Data (Niki L. Dimou, Konstantinos K. Tsilidis)....Pages 211-230 Copy Number Variation (Aurélien Macé, Zoltán Kutalik, Armand Valsesia)....Pages 231-258 From Identification to Function: Current Strategies to Prioritise and Follow-Up GWAS Results (Antonio J. Berlanga-Taylor)....Pages 259-275 Translating Human Genetics into Novel Drug Targets (Karol Estrada, Alzheimer’s Disease Neuroimaging Initiative)....Pages 277-290 Back Matter ....Pages 291-299