Pluripotent Stem Cells in Eye Disease Therapy

Description

This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases. Front Matter ....Pages i-xv Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective (Sonal Dalvi, Chad A. Galloway, Ruchira Singh)....Pages 1-31 Utility of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for an In Vitro Model of Proliferative Vitreoretinopathy (Whitney A. Greene, Ramesh R. Kaini, Heuy-Ching Wang)....Pages 33-53 Developing Cell-Based Therapies for RPE-Associated Degenerative Eye Diseases (Karim Ben M’Barek, Walter Habeler, Florian Regent, Christelle Monville)....Pages 55-97 Immunological Considerations for Retinal Stem Cell Therapy (Joshua Kramer, Kathleen R. Chirco, Deepak A. Lamba)....Pages 99-119 Advances in the Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells (Sarah K. Ohlemacher, Kirstin B. Langer, Clarisse M. Fligor, Elyse M. Feder, Michael C. Edler, Jason S. Meyer)....Pages 121-140 Surgical Approaches for Cell Therapeutics Delivery to the Retinal Pigment Epithelium and Retina (Boris Stanzel, Marius Ader, Zengping Liu, Juan Amaral, Luis Ignacio Reyes Aguirre, Annekatrin Rickmann et al.)....Pages 141-170 3D Engineering of Ocular Tissues for Disease Modeling and Drug Testing (M. E. Boutin, C. Hampton, R. Quinn, M. Ferrer, M. J. Song)....Pages 171-193 Back Matter ....Pages 195-201