ENGLISH

Recent Advances in Glucocorticoid Receptor Action

By K. Asadullah (eds.) , P. J. Barnes (auth.) , A. C. B. Cato , H. Schäcke

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2002
ISBN
978-3-662-04662-3, 978-3-662-04660-9
DOI
10.1007/978-3-662-04660-9
Language
english
Format
PDF
Filesize
8 MB (7912634 bytes)
Series
Ernst Schering Research Foundation Workshop 40
Edition
1
Pages
380\390
Time added
2013-12-12 02:00:00
Endocrinology; Molecular Medicine; Medical Biochem

Description

The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the sideeffects so far linked with classical glucocorticoids.

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