ENGLISH

Animal Models of T Cell-Mediated Skin Diseases

By H. Renz , M. Pasparakis (auth.) , T. Zollner , K. Asadullah (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2005
ISBN
978-3-540-21067-2, 978-3-540-26811-6
DOI
10.1007/b138119
Language
english
Format
PDF
Filesize
3 MB (3075718 bytes)
Series
Ernst Schering Research Foundation Workshop 50
Edition
1
Pages
291\301
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Dermatology; Cell Biology; Pneumology/Respiratory

Description

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

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