Targeted Therapies for Lung Cancer

Description

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance. Front Matter ....Pages i-ix EGFR Targeted Therapy (Zorawar S. Noor, Jonathan W. Goldman)....Pages 1-30 Anaplastic Lymphoma Kinase (Nicolas A. Villanueva, Nicholas P. Giustini, Lyudmila A. Bazhenova)....Pages 31-54 ROS1 (Leslie G. Oesterich, Jonathan W. Riess)....Pages 55-78 BRAF: Novel Therapies for an Emerging Target (Nathaniel J. Myall, Sukhmani K. Padda)....Pages 79-100 MET as a Therapeutic Target: Have Clinical Outcomes Been “MET” in Lung Cancer? (Arin Nam, Ravi Salgia)....Pages 101-123 Targeting HER2 in Lung Cancer (Ajaz Bulbul, Alessandro Leal, Hatim Husain)....Pages 125-136 NTRK-Targeted Therapy in Lung Cancer (Xiaoliang Wu, Lin Zhu, Patrick C. Ma)....Pages 137-161 Novel Therapies for Small Cell Lung Cancer (Marianna Koczywas, Idoroenyi Amanam)....Pages 163-178 Complexities of the Lung Tumor Microenvironment (Colt A. Egelston, Peter P. Lee)....Pages 179-194 KRAS-Mutated Lung Cancer (Arnab Basu, Jorge Nieva)....Pages 195-216 Targeting Epigenetic Regulators in Cancer to Overcome Targeted Therapy Resistance (Dan J. Raz)....Pages 217-232 Back Matter ....Pages 233-238