T-box Genes in Development and Disease

Description

T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease. Content: Series PagePage ii CopyrightPage iv ContributorsPages xi-xii PrefacePages xiii-xviiiManfred Frasch Chapter One - Evolution and Classification of the T-Box Transcription Factor FamilyPages 1-26A. Sebé-Pedrós, I. Ruiz-Trillo Chapter Two - The Remarkably Diverse Family of T-Box Factors in Caenorhabditis elegansPages 27-54P.G. Okkema Chapter Three - T-Box Genes and Developmental Gene Regulatory Networks in AscidiansPages 55-91A. Di Gregorio Chapter Four - Eomesodermin—At Dawn of Cell Fate Decisions During Early EmbryogenesisPages 93-115S. Probst, S.J. Arnold Chapter Five - Cooperation Between T-Box Factors Regulates the Continuous Segregation of Germ Layers During Vertebrate EmbryogenesisPages 117-159G.E. Gentsch, R.S. Monteiro, J.C. Smith Chapter Six - T-Box Genes in Drosophila Mesoderm DevelopmentPages 161-193I. Reim, M. Frasch, C. Schaub Chapter Seven - TBX5: A Key Regulator of Heart DevelopmentPages 195-221J.D. Steimle, I.P. Moskowitz Chapter Eight - Tbx1: Transcriptional and Developmental FunctionsPages 223-243A. Baldini, F.G. Fulcoli, E. Illingworth Chapter Nine - T-Box Genes in the Kidney and Urinary TractPages 245-278A. Kispert Chapter Ten - Control of Neuronal Development by T-Box Genes in the BrainPages 279-312A.B. Mihalas, R.F. Hevner Chapter Eleven - T-Box Genes in Drosophila Limb DevelopmentPages 313-354G.O. Pflugfelder, F. Eichinger, J. Shen Chapter Twelve - The Roles of T-Box Genes in Vertebrate Limb DevelopmentPages 355-381C.J. Sheeba, M.P.O. Logan Chapter Thirteen - T-Box Genes in Human Development and DiseasePages 383-415T.K. Ghosh, J.D. Brook, A. Wilsdon IndexPages 417-426