Hematopoietic Stem Cell Niche

Description

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments, such as new data on disease and clinical applications. Specific chapters delve into the evolution of hematopoietic stem cell niches, the role of CNS in the regulation of HSCs, and targeting the bone marrow niche in hematological malignancies. In addition, video content illustrates protocols, transplantation techniques, and work with mice. Content: CopyrightPage iv ContributorsPages vii-viii PrefacePage ixD. Bonnet Chapter One - Stroma Cell Niche Regulation During HSC DevelopmentPages 1-16G. Stik, P. Charbord, C. Durand Chapter Two - The Evolvement of Hematopoietic Stem Cell NichesPages 17-34B.O. Zhou, L. Li, M. Zhao Chapter Three - The Role of the CNS in the Regulation of HSCsPages 35-57A. García-García, S. Méndez-Ferrer Chapter Four - Imaging the Hematopoietic Stem Cell NichePages 59-83D. Duarte, C. Lo Celso Chapter Five - Mechanisms of Hematopoietic Stem and Progenitor Cells Bone Marrow Homing and MobilizationPages 85-121A. Kumari, K. Golan, E. Khatib-Massalha, O. Kollet, T. Lapidot Chapter Six - Alterations of HSC Niche in Myeloid MalignanciesPages 123-153L. Han, M. Konopleva Chapter Seven - Targeting the Bone Marrow Niche in Hematological MalignanciesPages 155-175D. Verma, D.S. Krause