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Current Topics in Cellular Regulation, Volume 5 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the role of phosphofructokinase in the regulation of glycolysis. This text then outlines the structural aspects of phosphofructokinase, its main kinetic properties, and the various mechanisms that have been proposed for its regulation. Other chapters consider the four-stage approach to analysis of control mechanisms. This book discusses as well the regulation of cellular function through the mechanism of protein phosphorylation. The final chapter deals with the pathway for histidine biosynthesis in Salmonella typhimurium, which consists of a series of reactions, each catalyzed by a specific enzyme. This book is a valuable resource for biologists and biochemists. Content: Contributors to Volume 5Page ii Front MatterPage iii Copyright pagePage iv List of ContributorsPage ix PrefacePage xiBERNARD L. HORECKER, EARL R. STADTMAN Contents of Previous VolumesPages xiii-xvi Phosphofructokinase*Pages 1-46TAG E. MANSOUR A Theoretical Background to the Use of Measured Concentrations of Intermediates in Study of the Control of Intermediary MetabolismPages 47-75F.S. ROLLESTON Memory MoleculesPages 77-97GÖTZ F. DOMAGK Protein Kinases*Pages 99-133EDWIN G. KREBS Glutamine Phosphoribosylpyrophosphate AmidotransferasePages 135-176JAMES B. WYNGAARDEN The Regulatory Influence of Allosteric Effectors on Deoxycytidylate DeaminasesPages 177-228FRANK MALEY, GLADYS F. MALEY The Citrate Enzymes: Their Structures, Mechanisms, and Biological FunctionsPages 229-283PAUL A. SRERE Regulation of Histidine Biosynthesis in Salmonella TyphimuriumPages 285-308ROBERT F. GOLDBERGER, JOHN S. KOVACH Author IndexPages 309-326 Subject IndexPages 327-331