ENGLISH

Intracellular Signal Transduction: The JAK-STAT Pathway

By Andrew F. Wilks , Ailsa G. Harpur (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1996
ISBN
978-3-662-22052-8, 978-3-662-22050-4
DOI
10.1007/978-3-662-22050-4
Language
english
Format
PDF
Filesize
10 MB (9966455 bytes)
Series
Molecular Biology Intelligence Unit
Edition
1
Pages
209\210
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cell Biology; Biochemistrygeneral; Cancer Research

Description

This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.

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