ENGLISH

Protein Degradation in Health and Disease

By Takumi Kamura , Joan W. Conaway (auth.) , Michèle Reboud-Ravaux (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2002
ISBN
978-3-642-62714-9, 978-3-642-56373-7
DOI
10.1007/978-3-642-56373-7
Language
english
Format
PDF
Filesize
3 MB (3165369 bytes)
Series
Progress in Molecular and Subcellular Biology 29
Edition
1
Pages
130\135
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cell Biology; Biochemistrygeneral; Cancer Research

Description

Protein degradation has been identified as a centerpiece of regulation of cell functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

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