Mitochondrial Inhibitors and Neurodegenerative Disorders

Description

In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins....Pages 3-19 History of 3-Nitropropionic Acid....Pages 21-33 The Neurochemistry of 3-Nitropropionic Acid....Pages 35-49 Front Matter....Pages 51-51 In Vitro Studies of 3-Nitropropionic Acid....Pages 53-72 Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats....Pages 73-92 Comparative Study on 3-Nitropropionic Acid Neurotoxicity....Pages 93-106 Mechanisms of 3-Nitropropionic Acid Neurotoxicity....Pages 107-120 Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery....Pages 121-127 Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid....Pages 129-140 The 3-Nitropropionic Acid Model of Huntington’s Disease....Pages 141-156 Mechanisms of Action of 3-Nitropropionic Acid....Pages 157-165 Mitochondrial Inhibition and Neuronal Death in Huntington’s Disease....Pages 167-176 Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrane Lipids and Proteins....Pages 177-200 Malonate....Pages 201-217 Malonic Acid and the Chronic Administration Model of Excitotoxicity....Pages 219-231 Sodium Azide-Induced Neurotoxicity....Pages 233-242 Front Matter....Pages 243-243 Neuroprotective Strategies Against Cellular Hypoxia....Pages 245-263 Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity....Pages 265-274 Neural Transplantation and Huntington’s Disease....Pages 275-291 Neuroprotective Strategies in Parkinson’s Disease and Huntington’s Chorea....Pages 293-309 Back Matter....Pages 311-313