Translational Advances in Gynecologic Cancers

Description

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Content: Front-matter,Dedication,Copyright,List of Contributors,Translational Advances in Gynecologic CancersEntitled to full textPart I: Ovarian CancerChapter 1 - Origins of Epithelial Ovarian Cancer, Pages 3-17, L. Dubeau, J. Teixeira Chapter 2 - Ovarian Cancer Genomics, Pages 19-34, L. Ceppi, M.J. Birrer Chapter 3 - Epigenetics, Pages 35-58, J.T. Pepin, H. Cardenas, K.P. Nephew, D. Matei Chapter 4 - Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma, Pages 59-78, C.M. St. Clair, F. Khoury-Collado, D.S. Chi Chapter 5 - Angiogenesis, Pages 79-109, A.A. Secord, S. Siamakpour-Reihani Chapter 6 - Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics, Pages 111-128, J.F. Liu, P.A. Konstantinopoulos Chapter 7 - Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy, Pages 129-150, B.L. Collins, A.N. Gonzalez, A. Hanbury, L. Ceppi, R.T. Penson Chapter 8 - Ovarian Cancer: New Targets and Future Directions, Pages 151-170, L.P. Martin, R.J. Schilder Chapter 9 - Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy, Pages 171-180, D.S. Dizon Chapter 10 - Updates on Rare Epithelial Ovarian Carcinoma, Pages 181-195, J. Bergstrom, I.-M. Shih, A.N. Fader Chapter 11 - Endometrial Cancer Genomics, Pages 199-227, M.E. Urick, D.W. Bell Chapter 12 - Sentinel Lymph Node Mapping Procedures in Endometrial Cancer, Pages 229-240, D.M. Boruta II Chapter 13 - The Role of Radiation in Uterine Cancer, Pages 241-259, A.L. Russo Chapter 14 - Novel Therapies for Advanced Cervical Cancer, Pages 263-299, K.S. Tewari Chapter 15 - New Therapies in Vulvar Cancer, Pages 303-312, M.H.M. Oonk, A.G.J. van der Zee Chapter 16 - Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery, Pages 315-332, M.E. Sabatini Index, Pages 333-338