Antiviral Compounds From Plants

Description

"This timely publication describes the botanical sources and chemical features of antiviral compounds. It covers their mechanisms of action and evaluates their therapeutic potential. Included is a discussion of synthetic analogues where appropriate. The book states that antiviral compounds in so-called medicinal plants may constitute some of their "active ingredients." It explains that many are photosensitizers, their antiviral activity dependent upon or augmented by light of specific wavelengths. This book is of value to microbiologists, phytochemists, virologists, natural-product chemists, ethnobotanists, pharmacologists, medical and veterinary researchers, and others interested in the application of plant compounds to therapy of infectious diseases."--Provided by publisher. Read more... Abstract: "This timely publication describes the botanical sources and chemical features of antiviral compounds. It covers their mechanisms of action and evaluates their therapeutic potential. Included is a discussion of synthetic analogues where appropriate. The book states that antiviral compounds in so-called medicinal plants may constitute some of their "active ingredients." It explains that many are photosensitizers, their antiviral activity dependent upon or augmented by light of specific wavelengths. This book is of value to microbiologists, phytochemists, virologists, natural-product chemists, ethnobotanists, pharmacologists, medical and veterinary researchers, and others interested in the application of plant compounds to therapy of infectious diseases."--Provided by publisher Content: Cover Title Page Copyright Page Table of Contents Chapter 1 Virus Infections I. Introduction II. Annotated Descriptions of Virus Infections A. Foot-and-Mouth Disease Virus B. Rabies Virus C. Fish Rhabdoviruses D. Polioviruses E. African Swine Fever Virus F. Hepatitis B Virus G. Newcastle Disease Virus H. Measles Virus I. Rinderpest Virus J. Influenza Viruses K. Herpes Viruses L. Bluetongue Virus M. Rotaviruses N. Rhinoviruses O. Rubella Virus P. Papilloma Viruses Q. Other Fish Viruses R. Human Immunodeficiency Virus-1 References Chapter 2 Viral Strategies in Replication, Persistence, and Transmission: Targets for ControlI. Classification of Animal Viruses II. Replication of Viruses: Targets for Control III. Persistence of Virus Infections IV. Variation of Viruses V. Mutation Frequency in Viral Genomes VI. Transmission of Viruses A. Horizontal Transmission within a Species B. Vertical Transmission C. Transmission between Species D. Transmission by Vectors References Chapter 3 Control of Virus Infections I. Introduction II. Limitations in the Use of Vaccines III. Chemotherapy IV. Disadvantages of Antiviral CompoundsV. Photochemotherapy VI. Monoclonal-Antibody Conjugates and Similar Approaches References Chapter 4 Methodology â#x80 #x94 A Critique I. Introduction II. Virus Assays and their Significance III. Variables in Virus Assays IV. Cellular Variables V. Animal Models VI. Changes in Infected Cells VII. Viral Targets References Chapter 5 The Choice and Use of Plant Materials I. Introduction II. Plant Extracts and Purified Compounds III. Evaluation of Pure Compounds IV. Evaluation of Crude Extracts â#x80 #x94 Pitfalls and Benefits V. Administration of CompoundsReferences Chapter 6 Photochemistry and Photosensitizers I. Introduction II. Photochemical Reactions III. Photosensitization IV. Photodynamic Effects on Viruses V. Action Spectra References Chapter 7 Furocoumarins and Related Compounds I. Introduction II. Antiviral Effects of Furocoumarins III. Mechanisms IV. Antiviral Properties of Furanochromones V. Summary References Chapter 8 Alkaloids I. Introduction II. β-Carbolines and Related Alkaloids III. Furanoquinolines IV. Camptothecin V. Atropine VI. Caffeine VII. Swainsonine VIII. CastanospermineIX. Papaverine X. Odorinol XI. Colchicum and Vinca Alkaloids XII. Catharanthus Alkaloids XIII. Other Alkaloids with Antiviral Properties XIV. Alkaloid Inhibitors of Reverse Transcriptase XV. Summary References Chapter 9 Polyacetylenes and Thiophenes I. Introduction II. Antiviral Effects of Polyacetylenes III. Mechanism of the Antiviral Action of Polyacetylenes IV. Antiviral Effects of Thiophenes V. Mechanism of the Antiviral Action of Thiophenes VI. Summary References Chapter 10 Flavonoids I. Introduction