Cytoskeleton of the Nervous System

Description

Without a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease. Front Matter....Pages i-xv Central Axonal Development and Pathology in Early Life....Pages 1-53 Microtubules in the Nervous System....Pages 55-71 Tau Phosphorylation....Pages 73-82 Tau Pathology....Pages 83-132 Tauopathy and Brain Aging....Pages 133-150 Microtubule-Associated Protein 4....Pages 151-165 Structure of Neural Intermediate Filaments....Pages 167-188 Alpha-Internexin: The Fourth Subunit of Neurofilaments in the Mature CNS....Pages 189-199 Peripherin Pathology....Pages 201-224 Neurofilament Cross-Bridge – A Structure Associated Specifically with the Neurofilament Among the Intermediate Filament Family....Pages 225-247 Neurofilament Transport....Pages 249-260 Knockout Models of Neurofilament Proteins....Pages 261-277 Neurofilaments and Radial Growth: Deconstruction of a Hypothesis Through the Construction of Gene Targeted Mice....Pages 279-295 Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration....Pages 297-324 Neurofilaments in Aged Animals....Pages 325-345 Neurofilament Changes in Multiple Sclerosis....Pages 347-377 Intermediate Filament Interactions in Neurons....Pages 379-410 Tropomyosins in Neuronal Morphogenesis and Development....Pages 411-445 The Driving Machinery for Growth Cone Navigation....Pages 447-454 Glial Fibrillary Acidic Protein: The Intermediate Filament Protein of Astrocytes....Pages 455-501 Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation....Pages 503-527 Axonal Transport and Motor Neuron Disease....Pages 529-544 In Vivo Imaging of Axonal Transport in Aging and Alzheimer’s Disease....Pages 545-558 Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease....Pages 559-602 Crosstalks Between Myelinating Cells and the Axonal Cytoskeleton....Pages 603-626 Topographic Regulation of Neuronal Intermediate Filament Proteins by Phosphorylation: In Health and Disease....Pages 627-656 Cytoskeleton, Axonal Transport, and the Mechanisms of Axonal Neuropathy....Pages 657-678 Effects of Insulin on Tau and Neurofilament....Pages 679-695 Ethanol Effects on the Cytoskeleton of Nerve Tissue Cells....Pages 697-758 Back Matter....Pages 759-774