Phosphorus Chemistry I : Asymmetric Synthesis and Bioactive Compounds

Description

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Read more... Abstract: Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field Front Matter ....Pages i-vii Phosphinic Peptides as Potent Inhibitors of Zinc-Metalloproteases (Dimitris Georgiadis, Vincent Dive)....Pages 1-38 Synthesis and Biological Applications of Phosphinates and Derivatives (David Virieux, Jean-Noël Volle, Norbert Bakalara, Jean-Luc Pirat)....Pages 39-114 Prodrugs of Phosphonates and Phosphates: Crossing the Membrane Barrier (Andrew J. Wiemer, David F. Wiemer)....Pages 115-160 Recent Advances in Asymmetric Synthesis of Р-Stereogenic Phosphorus Compounds (Oleg I. Kolodiazhnyi)....Pages 161-236 Back Matter ....Pages 237-242