Cancer Immunology

Description

This publication provides a comprehensive account of the known groups of human tumour antigens, and the immune effector cells involved in tumour rejection. Chapters dealing with all the major groups of human tumour antigens are included, covering differentiation antigens, testes-associated antigens, CEA, mucin, viral antigens, anti-idiotypic antibodies as antigens, and fusion proteins. The role of heat shock proteins as mediators of tumour immunity is discussed and consideration is given to the immune mechanisms which mediate tumour rejection in both human and animal systems. The application of antibody targeting to identify cancers, and the mechanisms by which tumours evade immune detection and/or destruction is covered in detail. Although the focus of this publication is experimental, as with other recent publications progress in clinical immunotherapy is included in some detail, to provide postgraduate and post-doctoral scientists with in-depth reviews of the field. Front Matter....Pages i-xxi Immunogenicity of tumour associated antigens....Pages 1-26 Recognition of human tumours: cancer/testis antigens....Pages 27-43 Recognition of human tumors: SEREX expression cloning to identify tumour antigens....Pages 45-57 Recognition of human tumours: melanoma differentiation antigens....Pages 59-72 Carcinoembryonic Antigen as a Vaccine Target....Pages 73-100 MUC1 mucin as a target for immunotherapy of cancer: Muc1 based immunotherapeutic strategies....Pages 101-122 Recognition of human tumours: viral antigens as immunological targets for cytotoxic T cells....Pages 123-145 The immune response to oncogenic fusion proteins....Pages 147-156 Immunological significance of hsp70 in tumor rejection....Pages 157-169 Anti-idiotypic vaccination....Pages 171-180 Genetically modified tumour cells for cancer immunization....Pages 181-194 Antibody targeted therapy: delivery of radionuclides, toxins and drugs....Pages 195-217 Escape Mechanisms in Tumour Immunity....Pages 219-247 Back Matter....Pages 249-253