2022 Nelson's Pediatric Antimicrobial Therapy

Description

Completely updated and revised, the 28th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children.   For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens.   TOPICS INCLUDE Antimicrobial Therapy by Clinical SyndromesAntimicrobial Therapy for NeonatesChoosing AmongAntibioticsAntifungal AgentsAntiviral AgentsAntiparasitic AgentsOral Step-down Therapy for Serious InfectionsPrevention of Symptomatic InfectionApproach to Antibiotic AllergiesAntibiotic StewardshipNew in the 28th EditionUpdated recommendations on acute hematogenous osteomyelitis, based on newly published guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America, including information on a decrease in the incidence of MRSA infections, allowing the recommendation of cefazolin, again, in empiric therapy for most pediatric bone infectionsUpdated recommendations on influenza treatment and prophylaxis, reflecting American Academy of Pediatrics guidance for 2021–2022Ceftazidime/avibactam now preferred over fluoroquinolones for treatment of Klebsiella pneumoniae carbapenemase–producing enteric bacilli, if susceptibleCefiderocol, a new iron-binding siderophore cephalosporin class, recently approved in adults for treatment of many drug-resistant pathogens, particularly Acinetobacter, Stenotrophomonas, and Pseudomonas; under study in childrenNew dosing for posaconazole suspension formulationNew approaches to mucormycosisAdded baloxavir for children 12+ years oldOnline updates of COVID-19 therapies once emergency use authorization in children at http://www.aap.org/nelsonsUpdated Nelson’s app also available   Front Matter 1. Antimicrobial Therapy According to Clinical Syndromes 2. Antimicrobial Therapy for Neonates 3. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens 4. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones 5. Preferred Therapy for Specific Fungal Pathogens 6. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins 7. Preferred Therapy for Specific Viral Pathogens 8. Choosing Among Antiviral Agents 9. Preferred Therapy for Specific Parasitic Pathogens 10. Choosing Among Antiparasitic Agents: Antimalarial Drugs, Nitroimidazoles, Benzimidazoles, and Neglected Tropical Diseases 11. How Antibiotic Dosages Are Determined Using Susceptibility Data, Pharmacodynamics, and Treatment Outcomes 12. Approach to Antibiotic Therapy for Drug-Resistant Gram-negative Bacilli and Methicillin-Resistant Staphylococcus aureus 13. Antibiotic Therapy for Children Who Are Obese 14. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy) for Serious Infections 15. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection 16. Approach to Antibiotic Allergies 17. Antibiotic Stewardship 18. Systemic and Topical Antimicrobial Dosing and Dose Forms Appendix: Nomogram for Determining Body Surface Area References Index