2020 Nelson’s Pediatric Antimicrobial Therapy

Description

The 26th edition provides practical, evidence-based recommendations from the experts in antimicrobial therapy for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help health care providers select the best of all antimicrobial choices. Drug descriptions cover pediatric-appropriate antimicrobial agents available today and include complete information about dosing regimens. New in the 26th edition: First pediatric approval of beta-lactam/beta-lactamase inhibitor for CRE (carbapenem-resistant enteric bacilli), ceftazidime-avibactam Replacement antibiotics for cefotaxime (lack of availability in the US), including ceftriaxone and cefepime (for neonates) Situations in which ceftaroline is preferred over vancomycin by the Editors for MRSA infections Updates on management of influenza, including baloxavir (now approved for children >12 years) New approaches to treatment of mucomycosis New recommendations for malaria More than 150 new references! 1. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones......Page 13 2. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins......Page 21 3. How Antibiotic Dosages Are Determined Using Susceptibility Data, Pharmacodynamics, and Treatment Outcomes......Page 31 4. Approach to Antibiotic Therapy of Drug-Resistant Gram-negative Bacilli and Methicillin-Resistant Staphylococcus aureus......Page 35 5. Antimicrobial Therapy for Newborns......Page 43 A. Recommended Therapy for Selected Newborn Conditions......Page 45 B. Antimicrobial Dosages for Neonates......Page 67 C. Aminoglycosides......Page 71 E. Use of Antimicrobials During Pregnancy or Breastfeeding......Page 72 6. Antimicrobial Therapy According to Clinical Syndromes......Page 75 A. Skin and Soft Tissue Infections......Page 78 B. Skeletal Infections......Page 84 C. Eye Infections......Page 87 D. Ear and Sinus Infections......Page 91 E. Oropharyngeal Infections......Page 94 F. Lower Respiratory Tract Infections......Page 97 G. Cardiovascular Infections......Page 110 H. Gastrointestinal Infections......Page 117 I. Genital and Sexually Transmitted Infections......Page 124 J. Central Nervous System Infections......Page 128 K. Urinary Tract Infections......Page 133 L. Miscellaneous Systemic Infections......Page 135 7. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 143 A. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Positive)......Page 144 B. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Negative)......Page 146 C. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Anaerobes)......Page 148 D. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 150 8. Preferred Therapy for Specific Fungal Pathogens......Page 171 A. Overview of More Common Fungal Pathogens and Their Usual Pattern of Antifungal Susceptibilities......Page 172 B. Systemic Infections......Page 174 C. Localized Mucocutaneous Infections......Page 188 9. Preferred Therapy for Specific Viral Pathogens......Page 189 B. Overview of Hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals......Page 190 C. Preferred Therapy for Specific Viral Pathogens......Page 192 10. Preferred Therapy for Specific Parasitic Pathogens......Page 207 A. Selected Common Pathogenic Parasites and Suggested Agents for Treatment......Page 208 B. Preferred Therapy for Specific Parasitic Pathogens......Page 210 11. Alphabetic Listing of Antimicrobials......Page 231 A. Systemic Antimicrobials With Dosage Forms and Usual Dosages......Page 233 B. Topical Antimicrobials (Skin, Eye, Ear, Mucosa)......Page 256 12. Antibiotic Therapy for Children Who Are Obese......Page 263 13. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy) for Serious Infections......Page 267 14. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection......Page 269 A. Postexposure Antimicrobial Prophylaxis to Prevent Infection......Page 271 B. Long-term Antimicrobial Prophylaxis to Prevent Symptomatic New Infection......Page 277 C. Prophylaxis of Symptomatic Disease in Children Who Have Asymptomatic Infection/Latent Infection......Page 278 D. Surgical/Procedure Prophylaxis......Page 281 Appendix: Nomogram for Determining Body Surface Area......Page 287 References......Page 289 Index......Page 313