Neurotransmitter Transporters: Structure, Function, and Regulation

Description

Integrating the many recent advances from DNA technology, Maarten Reith and his contributors fully update all the material in his highly acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis studies, and transporter electrophysiology. Many chapters will be of interest to physicians carrying out imaging and postmortem measurements of neurotransmitter transporters in the human brain, and to physicians who study the relation of gene linkages and polymorphisms to psychiatric and other complex human diseases. Complete and up-to-date, Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of this most active field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move work on another transporter forward. Front Matter....Pages i-xii Regulation of Monoamine Transporters....Pages 1-23 Mechanisms of Biogenic Amine Neurotransmitter Transporters....Pages 25-52 Structure-Function Relationships for Biogenic Amine Neurotransmitter Transporters....Pages 53-109 Gene Organization and Polymorphisms of Monoamine Transporters....Pages 111-169 Monoamine Transporters....Pages 171-192 Family of Sodium-Coupled Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine....Pages 193-233 Sodium-Coupled GABA and Glutamate Transporters....Pages 235-254 The High-Affinity Glutamate and Neutral Amino-Acid Transporter Family....Pages 255-311 Vesicular Neurotransmitter Transporters....Pages 313-354 Neurotransmitter-Transporter Proteins....Pages 355-380 Dopamine-Transporter Uptake Blockers....Pages 381-432 Imaging the Brain Dopamine Transporter Using PET and SPECT....Pages 433-465 In Vitro and In Vivo Imaging of the Human Dopamine Transporter in Cocaine Abusers....Pages 467-501 Back Matter....Pages 503-518