Zic family: Evolution, Development and Disease

Description

This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine. Front Matter ....Pages i-x Front Matter ....Pages 1-1 Comparative Genomics of the Zic Family Genes (Jun Aruga, Minoru Hatayama)....Pages 3-26 Cnidarian Zic Genes (Michael J. Layden)....Pages 27-39 Odd-Paired: The Drosophila Zic Gene (Deborah A. Hursh, Brian G. Stultz)....Pages 41-58 Zic Genes in Nematodes: A Role in Nervous System Development and Wnt Signaling (Guillaume Bordet, Vincent Bertrand)....Pages 59-68 Lophotrochozoan Zic Genes (Jun Aruga)....Pages 69-86 Ascidian Zic Genes (Yutaka Satou, Kaoru S. Imai)....Pages 87-106 Amphibian Zic Genes (Christa Merzdorf, Jennifer Forecki)....Pages 107-140 Zic Genes in Teleosts: Their Roles in Dorsoventral Patterning in the Somite (Kota Abe, Toru Kawanishi, Hiroyuki Takeda)....Pages 141-156 Zebrafish Zic Genes Mediate Developmental Signaling (Cecilia Lanny Winata, Vladimir Korzh)....Pages 157-177 Overview of Rodent Zic Genes (Koula E. M. Diamand, Kristen S. Barratt, Ruth M. Arkell)....Pages 179-207 Rodent Zic Genes in Neural Network Wiring (Eloísa Herrera)....Pages 209-230 Front Matter ....Pages 231-231 Zic Family Proteins in Emerging Biomedical Studies (Jun Aruga)....Pages 233-248 ZIC1 Function in Normal Cerebellar Development and Human Developmental Pathology (Jun Aruga, Kathleen J. Millen)....Pages 249-268 ZIC2 in Holoprosencephaly (Kristen S. Barratt, Ruth M. Arkell)....Pages 269-299 ZIC3 in Heterotaxy (Helen M. Bellchambers, Stephanie M. Ware)....Pages 301-327 Deregulation of ZIC Family Members in Oncogenesis (Rob Houtmeyers, Jabob Souopgui, Sabine Tejpar)....Pages 329-338 Roles of ZIC2 in Regulation of Pluripotent Stem Cells (Hisato Kondoh)....Pages 339-351 Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling (Minoru Hatayama, Jun Aruga)....Pages 353-380