ENGLISH

Oxidative Folding of Peptides and Proteins

By Johannes Buchner , Luis Moroder

Book information

Publisher
Royal Society of Chemistry
Year
2009
ISBN
9780854041480, 0854041486
Language
english
Format
PDF
Filesize
20 MB (20573426 bytes)
Series
RSC Biomolecular Sciences
Edition
1
Pages
451\451
Library
duansci.com
Time added
2010-05-17 00:23:50

Description

This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines.

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