ENGLISH

Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes

By Professor Yechiel Becker , Professor Gholamreza Darai (eds.) , Yechiel Becker , Eynat Tabor , Yael Asher , Mirta Grifman , Yosef Kleinman , Avner Yayon (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1994
ISBN
978-3-642-85006-6, 978-3-642-85004-2
DOI
10.1007/978-3-642-85004-2
Language
english
Format
PDF
Filesize
21 MB (22207710 bytes)
Series
Frontiers of Virology 3
Edition
1
Pages
387\390
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
general; Internal MedicineVirology; Microbiology; Cell Biology; Biochemistry

Description

Six members of the Herpesviridae family are human pathogens, including herpes and 2 (HSV-I and 2), Epstein-Barr virus (EBV), varicella zoster simplex virus I virus (VZV), human cytomegalovirus (HCMV), and human herpesvirus 6 (HHV 6). Each of these viruses is capable of causing distinct diseases of varying severity in children, young adults, and the aged. The diseases range from infection of epithelial tissue to the infection of internal organs and white blood cells. A common feature of the six pathogenic human herpesviruses is their ability to latently infect different cell types in which the viral DNA is not integrated and is unable to express its pathogenicity. Reactivation of the herpesviruses is a result of cellular processes which reactivate viral genes, leading to virus progeny and to signs of infection. Due to their ability to become latent after initial infection, once the pathogenic herpesviruses infect children they are maintained throughout life, having the potential of cause various diseases upon reactivation.

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