Treatment of Inflammatory Bowel Disease with Biologics

Description

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease. Front Matter ....Pages i-xi Mechanism of Action and Pharmacokinetics of Biologics (Alan C. Moss)....Pages 1-11 Antitumor Necrosis Factor Agents in Ulcerative Colitis (Kindra Clark-Snustad, Ives Hot, Scott Lee)....Pages 13-32 Antitumor Necrosis Factor Agents in Crohn’s Disease (Byron P. Vaughn)....Pages 33-48 Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease (David I. Fudman, Sarah N. Flier)....Pages 49-57 Use of Biologics in the Postoperative Management of Crohn’s Disease (Benjamin H. Click, Miguel Regueiro)....Pages 59-79 Biologics in Pregnancy and Breastfeeding (Jill K. J. Gaidos, Sunanda V. Kane)....Pages 81-99 Concomitant Use of Immunosuppressive Therapy with Tumor Necrosis Factor (TNF) Antagonists in Inflammatory Bowel Disease (Parambir S. Dulai, Corey A. Siegel)....Pages 101-112 Therapeutic Drug Monitoring of Biologic Agents (Frank I. Scott, Mark T. Osterman)....Pages 113-128 Use of Biologics in Crohn’s Disease and Ulcerative Colitis Prior to Surgery and Perioperative Risks (Afrin Kamal, Bret Lashner)....Pages 129-140 Cessation of Biologics: Can It Be Done? (Hang Hock Shim, Cynthia H. Seow)....Pages 141-162 Biologic Therapy in Pediatric Inflammatory Bowel Disease (Sonal Patel, Jennifer Strople)....Pages 163-183 Infectious Complications of Biologics (Renée M. Marchioni Beery, Joshua R. Korzenik)....Pages 185-211 Tumor Necrosis Factor-Alpha Inhibitors and Risks of Malignancy (Julia T. Hughes, Millie D. Long)....Pages 213-229 Noninfectious and Nonmalignant Complications of Anti-TNF Therapy (Uni Wong, Raymond K. Cross)....Pages 231-260 Biosimilars in Inflammatory Bowel Disease 2017: State of the Science, State of the Art, and State of the Finances (Christina Y. Ha, Asher Kornbluth)....Pages 261-282 Anti-integrin Agents in IBD: Efficacy and Risk of Complications (Jimmy K. Limdi, Francis A. Farraye)....Pages 283-301 Novel Agents in Inflammatory Bowel Disease (Fernando Velayos)....Pages 303-313 Quality, Safety, and Practical Considerations of Using Biologic Therapies (Leilei Zhu, Gil Y. Melmed)....Pages 315-328 Back Matter ....Pages 329-335