Colonic Diseases

Description

With an aging population prone to colorectal disorders and with the quickening pace of medical discovery, there is a need for an up-to-date survey of the field. In Colonic Diseases, Timothy R. Koch, MD, has assembled a panel of innovative basic researchers, esteemed clinical investigators, and well-known clinicians to bridge the gap between basic and clinical research and the day-to-day care of patients with colonic disorders. As a foundation for better understanding, the authors review what is currently known about normal colonic physiology, explain the mechanisms of disease involved in the development of colonic disorders, and highlight important clues for potential therapies. Their review of the diagnosis and treatment of common colonic disorders covers colorectal neoplasia, inflammatory bowel disease (IBD), ulcerative colitis, diverticular disease, Crohn's disease, and constipation. Here the authors fully discuss potential symptoms, pathological and radiological findings, the differential diagnosis, and presently recommended modes of evaluation and therapy, including the use of probiotics. New areas of potential treatment not presently available for patients with chronic symptoms are also examined, along with the advanced treatment techniques currently in use at the Cleveland Clinic (for ulcerative colitis), The University of Chicago (for Crohn's disease), the Mayo Clinic (for irritable bowel syndrome), and the MD Anderson Cancer Center (for colorectal cancer). Timely and cutting-edge, Colonic Diseases explains the origins and treatment of common colorectal disorders, blending the molecular mechanisms of disease with new outcomes and epidemiological research to improve our present and future understanding of colonic diseases and their management. Front Matter....Pages i-xviii Front Matter....Pages 1-1 Absorption—Secretion and Epithelial Cell Function....Pages 3-23 Normal Motility and Smooth Muscle Function....Pages 25-33 Neural Regulation of Colonic Motor Function....Pages 35-52 Mucin and Goblet Cell Function....Pages 53-71 Endocrine Cells of the Colon....Pages 73-84 Micronutrients....Pages 85-93 Aging....Pages 95-104 Immunology of the Gastrointestinal Tract....Pages 105-122 Colonic Lymphatics....Pages 123-140 Probiotics and the Colon....Pages 141-161 Physiology and Pathophysiology of Colorectal Sensory Processes....Pages 163-175 Front Matter....Pages 177-177 Oxidative Stress....Pages 179-189 Genetic Testing for Colon Cancer....Pages 191-210 Inflammation....Pages 211-225 Epidemiologic Studies and Outcomes Research in Colonic Diseases....Pages 227-242 Colonoscopy....Pages 243-274 Interpretation of Colonic Biopsies in Patients with Diarrhea....Pages 275-295 Anorectal Manometry....Pages 297-319 Endoanal and Endorectal Ultrasound....Pages 321-333 Colonic Transit and Motility....Pages 335-343 Front Matter....Pages 177-177 Defecography and Related Radiologic Imaging Techniques....Pages 345-356 Cross-Sectional Imaging of the Large Bowel....Pages 357-380 Front Matter....Pages 381-381 Hirschsprung’s Disease and Neonatal Disorders....Pages 383-393 Acute Megacolon, Acquired Megacolon, and Volvulus....Pages 395-407 Diverticular Disease....Pages 409-421 Current Understanding of Colorectal Neoplasia....Pages 423-439 Constipation....Pages 441-457 Crohn’s Disease....Pages 459-478 Ulcerative Colitis....Pages 479-489 Irritable Bowel Syndrome....Pages 491-504 Ischemic Colitis....Pages 505-521 Surgical Treatments for Colonic Diseases....Pages 523-534 Anorectal Disorders....Pages 535-543 Back Matter....Pages 545-553