RNA Modification

Description

RNA Modification, Volume 41 examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. Chapters in this newly released volume include The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and Dynamics, The evolution of multi-substrate specificity by RNA modification enzymes, TrmD: a methyl transferase for tRNA methylation with m1G37, Structures and activities of the Elongator complex and its co-factors, RNA pseudouridylation: Mechanism and Function, The activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAs, and the Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAs. This field has recently seen a very rapid progress in the understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules. Content: CopyrightPage iv ContributorsPages ix-x PrefacePage xiGuillaume F. Chanfreau Chapter One - The Importance of Being Modified: The Role of RNA Modifications in Translational FidelityPages 1-50Paul F. Agris, Amithi Narendran, Kathryn Sarachan, Ville Y.P. Väre, Emily Eruysal Chapter Two - The Evolution of Substrate Specificity by tRNA Modification EnzymesPages 51-88Katherine M. McKenney, Mary Anne T. Rubio, Juan D. Alfonzo Chapter Three - TrmD: A Methyl Transferase for tRNA Methylation With m1G37Pages 89-115Ya-Ming Hou, Ryuma Matsubara, Ryuichi Takase, Isao Masuda, Joanna I. Sulkowska Chapter Four - Structures and Activities of the Elongator Complex and Its CofactorsPages 117-149Olga Kolaj-Robin, Bertrand Séraphin Chapter Five - Posttranscriptional RNA PseudouridylationPages 151-167Meemanage D. De Zoysa, Yi-Tao Yu Chapter Six - Synthesis, Function, and Heterogeneity of snoRNA-Guided Posttranscriptional Nucleoside Modifications in Eukaryotic Ribosomal RNAsPages 169-213Anthony K. Henras, Célia Plisson-Chastang, Odile Humbert, Yves Romeo, Yves Henry Chapter Seven - Adenosine Deaminases That Act on RNA (ADARs)Pages 215-268Yuru Wang, Yuxuan Zheng, Peter A. Beal Chapter Eight - Reading the Epitranscriptome: New Techniques and PerspectivesPages 269-298Lee E. Vandivier, Brian D. Gregory Chapter Nine - Impact of RNA Modifications and RNA-Modifying Enzymes on Eukaryotic RibonucleasesPages 299-329Guillaume F. Chanfreau