Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis

Description

Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis deals with the use of high-resolution mass spectrometry (MS) in the analysis of small organic molecules. Over the past few years, time-of-flight (ToF) and Orbitrap MS have both experienced tremendous growth in a great number of analytical sectors and are now well established in many laboratories where high requirements are placed on analytical performance. This book gives a head-to-head comparison of these two technologies that compete directly with each other. As users with hands-on experience in both techniques, the authors provide a balanced description of the strengths and weaknesses of both techniques. In the vast majority of cases, ToF-MS and Orbitrap-MS have been used for qualitative purposes, mainly identification of discrete molecular entities such as drug metabolites or transformation products of environmental contaminants. This paradigm is now changing as quantitative capabilities are increasingly being explored, as are non-target approaches for unbiased broad-scope screening. In view of the continuous innovation of high-resolution MS instrument manufacturers in designing and developing more powerful machines, technological advances in both hardware and software are considerable, with many novel applications. This book summarizes and analyzes these trends. The compilation of selected examples from diverse analytical fields will allow the readers to discover not only the potential of high-resolution MS in their sector, but also shows advances in other fields that rely on hi-res MS. Content: Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic AnalysisPage i Advisory BoardPage ii Front MatterPage iii CopyrightPage iv Contributors to Volume 71Pages xiii-xv Series Editor's PrefacePage xviiD. Barceló PrefacePages xix-xxiSandra Pérez, Peter Eichhorn, Dami`Barceló Chapter 1 - Orbitrap Mass Spectrometry: Evolution and ApplicabilityOriginal Research ArticlePages 3-18C.P.B. Martins, M. Bromirski, M.C. Prieto Conaway, A.A. Makarov Chapter 2 - Advances in Time-of-Flight Mass SpectrometryOriginal Research ArticlePages 19-49J.C. Fjeldsted Chapter 3 - Ambient Ionisation–High-Resolution Mass Spectrometry: Environmental, Food, Forensic and Doping analysisOriginal Research ArticlePages 51-88R. Seró, Ó. Núñez, E. Moyano Chapter 4 - High-Resolution Mass Spectrometry in Doping ControlOriginal Research ArticlePages 91-117G. Balcells, O.J. Pozo, R. Ventura Chapter 5 - Application of LC-Time-of-Flight and Orbitrap-MS/MS for Pesticide Residues in Fruits and VegetablesOriginal Research ArticlePages 119-154Ł. Rajski, M.M. Gómez-Ramos, A.R. Fernández-Alba Chapter 6 - Identification of Sildenafil Designer Analogues Found in Dietary SupplementsOriginal Research ArticlePages 155-197X. Ge, C.-L. Kee, Y. Zeng, M.-Y. Low Chapter 7 - High-Resolution Mass Spectrometry in Metabolite IdentificationOriginal Research ArticlePages 199-229M.K. Ladumor, S. Tiwari, A. Patil, K. Bhavsar, S. Jhajra, B. Prasad, S. Singh Chapter 8 - LC-TOF-MS for the Identification of Environmental Metabolites and Degradation ProductsOriginal Research ArticlePages 231-261I. Ferrer, J.H. Writer, O.S. Keen, Y. Lester, J.A. Padilla-Sánchez, C. Fernández-Ramos, E.M. Thurman Chapter 9 - Application of Orbitrap Mass Spectrometry for the Identification of Transformation Products of Trace Organic Contaminants Formed in the EnvironmentOriginal Research ArticlePages 263-282C. Prasse, T.A. Ternes Chapter 10 - High-Resolution Mass Spectrometry Identification of Micropollutants Transformation Products Produced During Water Disinfection With Chlorine and Related ChemicalsOriginal Research ArticlePages 283-334I. González-Mariño, I. Carpinteiro, R. Rodil, I. Rodríguez, J.B. Quintana Chapter 11 - Discovery of New Emerging DBPs by High-Resolution Mass SpectrometryOriginal Research ArticlePages 335-356S.D. Richardson, C. Postigo Chapter 12 - Suspect Screening of Pharmaceuticals and Related Bioactive Compounds, Their Metabolites and Their Transformation Products in the Aquatic Environment, Biota and Humans Using LC-HR-MS TechniquesOriginal Research ArticlePages 357-378J. Aceña, N. Heuett, P. Gardinali, S. Pérez Chapter 13 - Nontarget Analysis of Environmental Samples Based on Liquid Chromatography Coupled to High Resolution Mass Spectrometry (LC-HRMS)Original Research ArticlePages 381-403P. Gago-Ferrero, E.L. Schymanski, J. Hollender, N.S. Thomaidis Chapter 14 - Nontargeted Analysis of Persistent Organic Pollutants by Mass Spectrometry and GC×GCOriginal Research ArticlePages 405-431X. Ortiz-Almirall, M. Pena-Abaurrea, K.J. Jobst, E.J. Reiner Chapter 15 - High-Resolution Mass Spectrometry in the Effect-Directed Analysis of Water ResourcesOriginal Research ArticlePages 433-457M. Krauss Chapter 16 - Conclusions and Future DirectionsOriginal Research ArticlePages 461-480P. Eichhorn, S. Pérez IndexPages 481-501