Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine

Description

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Cover Evolution’s Clinical Guidebook: Translating Ancient Genes into Precision Medicine Copyright Other Books by Jules J. Berman About the Author Preface References 1 Evolution, From the Beginning Section 1.1 In the Beginning Section 1.2 Bootstrapping Paradoxes Section 1.3 Our Genes, for the Most Part, Come From Ancestral Species Section 1.4 How do Metabolic Pathways Evolve? Section 1.5 Cambrian Explosion Section 1.6 After the Cambrian: Coexistence and Coevolution Glossary References 2 Shaking Up the Genome Section 2.1 Mutation Burden Section 2.2 Gene Pools and Gene Conservation Section 2.3 Recombination and Other Genetic Tricks Section 2.4 Genomic Architecture: An Evolutionary Free-for-All Section 2.5 Rummaging Through the DNA Junkyard Glossary References 3 Evolution and Embryonic Development Section 3.1 The Tight Relationship Between Evolution and Embryology Section 3.2 The Epigenome and the Evolution of Cell Types Section 3.3 An Embryonic Detour for Human Diseases Section 3.4 The Borderland of Embryology and Cancer Section 3.5 Pathologic Conditions of the Genomic Regulatory Systems Glossary References 4 Speciation Section 4.1 A Species is a Biological Entity Section 4.2 The Biological Process of Speciation Section 4.3 The Diversity of Living Organisms Section 4.4 The Species Paradox Section 4.5 Viruses and the Meaning of Life Glossary References 5 Phylogeny: Eukaryotes to Chordates Section 5.1 On Classification Section 5.2 The Complete Human Phylogenetic Lineage Section 5.3 Eukaryotes to Obazoans Section 5.4 Opisthokonts to Parahoxozoa Section 5.5 Bilaterians to Chordates Glossary References 6 Phylogeny: Craniates to Humans Section 6.1 Class Craniata and the Ascent of the Neural Crest Section 6.2 Vertebrates to Synapsids Section 6.3 Mammals to Therians Section 6.4 Eutherians to Humans Glossary References 7 Trapped by Evolution Section 7.1 Spandrels, Pendentives, Corbels, and Squinches Section 7.2 Evolving Backwards Section 7.3 Eugenics: Proceed With Caution Section 7.4 The Evolution of Aging, and the Diseases Thereof Section 7.5 Why Good People Get Bad Diseases Glossary References 8 Animal Models of Human Disease: Opportunities and Limitations Section 8.1 The Animal Model Problem, in a Nutshell Section 8.2 Specificities and Idiosyncrasies Section 8.3 New Animal Options Section 8.4 The Proper Study of Mankind Glossary References 9 Medical Proof of Evolution Section 9.1 What Does Proof Mean, in the Biological Sciences? Section 9.2 The Differences Between Designed Organisms and Evolved Organisms Section 9.3 What if Evolution Were Just a Foolish Fantasy Glossary References Index A B C D E F G H I J K L M N O P R S T U V W X Y Z Back Cover