Tocotrienols : vitamin E beyond tocopherols

Description

"A New Avenue of Research Beyond Traditional Studies of Vitamin E. The first 90 years of vitamin E research has produced prolific and notable discoveries. Until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Tocotrienol discovery came much later, in 1965, but existed for almost 20 years as an obscure vitamin E. Explores Treatment Possibilities: Tocotrienols have proven to contain some exceptional benefits that aren't shared by the better known tocopherols. Although both are antioxidants, today a bright spot for tocotrienol research is in cancer and heart disease, while emergent fields of tocotrienol research are on the rise with many covered in this edition. Currently, tocotrienols have reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years was published in the last 3 years. The thriving field of tocotrienol research gives ground for publication of this 2nd edition, a compilation of the latest tocotrienol research in all new chapters. For the past 10 years, Professors Ronald R. Watson and Victor R. Preedy have published books on bioactive nutrients and dietary supplements. Professor Watson has been and is currently funded to do research by grants from the American Heart Foundation and the U.S. National Institute of Heart, Lung, and Blood. By gathering the contributions contained in this volume, they have expanded the field of knowledge and forged a new path in disease treatment and prevention"--Provided by publisher. Read more... Content: Ch. 1. Tocotrienols in plants : occurrence, biosynthesis, and function / Maren Müller ... [et al.] -- ch. 2. Safety of unsaturated vitamin E tocotrienols and their isomers / Alexander G. Schauss, John R. Endres, and Amy Clewell -- ch. 3. Bioavailability and metabolism of tocotrienols / Zhihong Yang ... [et al.] -- ch. 4. Bioavailability of tocotrienols and interference of their bioavailability by [alpha]-tocopherol supplementation / Saiko Ikeda, Tomono Uchida, and Chisato Abe -- ch. 5. Alpha-tocopherol : a detriment to tocotrienol benefits / Anne M. Trias and Barrie Tan -- ch. 6. Antiangiogenic effects of tocotrienol / Takahiro Eitsuka, Kiyotaka Nakagawa, and Teruo Miyazawa -- ch. 7. Mechanism of delta-tocotrienol on colorectal cancer / Sayori Wada and Yuji Naito -- ch. 8. Targeted prostate cancer chemoprevention trial with tocotrienols / William L. Stone ... [et al.] -- ch. 9. [delta]-tocotrienol : demethylated vitamin E with hormetic function and therapeutic application in breast cancer / Francesca Pilolli ... [et al.] -- ch. 10. Mevalonate-suppressive tocotrienols for cancer chemoprevention and adjuvant therapy / Huanbiao Mo ... [et al.] -- ch. 11. Potential of tocotrienols in lung cancer / Xiangming Ji, Arvind Goja, and Smiti V. Gupta -- ch. 12. Tocotrienols and atherosclerosis : potential in cardioprotection / Hapizah Mohd Nawawi -- ch. 13. Tocotrienols : viable options for managing metabolic diseases / Chi-Wai Wong -- ch. 14. Tocotrienols as possible treatments for obesity / Wong Weng-Yew and Lindsay Brown -- ch. 15. Tocotrienols, inflammation, and cancer : how are they linked? / Sahdeo Prasad ... [et al.] -- ch. 16. 1-modulating NF-[kappa]B activity by tocotrienols / Mary Kaileh and Ranjan Sen -- ch. 17. Antioxidant action of tocotrienols / Etsuo Niki -- ch. 18. Tocotrienol in human pancreatic cancer / Mokenge P. Malafa and Kazim Husain -- ch. 19. Tocotrienols in the treatment of dyslipidemia / Mark Houston -- ch. 20. Tocotrienols and vascular effects / Aida Hanum Ghulam Rasool -- ch. 21. Prolongevity effects of tocotrienols : trials in Caenorhabditis elegans / Noriko Kashima ... [et al.] -- ch. 22. Anti-tyrosinase activity of tocotrienol in skin blemishes / Daniel Yee Leng Yap -- ch. 23. Tocotrienols and bone health / Ima Nirwana Soelaiman ... [et al.] -- ch. 24. Tocotrienol and physiology of reproduction / M.H. Rajikin ... [et al.] -- ch. 25. Tocotrienol and tocopherol in stress-induced gastric mucosal injury / Nafeeza Mohd Ismail and Ibrahim Abdel Aziz Ibrahim -- ch. 26. Structural modification of tocotrienols to improve bioavailability / Awantika Singh ... [et al.] Abstract: "A New Avenue of Research Beyond Traditional Studies of Vitamin E. The first 90 years of vitamin E research has produced prolific and notable discoveries. Until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Tocotrienol discovery came much later, in 1965, but existed for almost 20 years as an obscure vitamin E. Explores Treatment Possibilities: Tocotrienols have proven to contain some exceptional benefits that aren't shared by the better known tocopherols. Although both are antioxidants, today a bright spot for tocotrienol research is in cancer and heart disease, while emergent fields of tocotrienol research are on the rise with many covered in this edition. Currently, tocotrienols have reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years was published in the last 3 years. The thriving field of tocotrienol research gives ground for publication of this 2nd edition, a compilation of the latest tocotrienol research in all new chapters. For the past 10 years, Professors Ronald R. Watson and Victor R. Preedy have published books on bioactive nutrients and dietary supplements. Professor Watson has been and is currently funded to do research by grants from the American Heart Foundation and the U.S. National Institute of Heart, Lung, and Blood. By gathering the contributions contained in this volume, they have expanded the field of knowledge and forged a new path in disease treatment and prevention"--Provided by publisher