Graphene Based Biomolecular Electronic Devices

Description

Graphene Based Biomolecular Electronic Devices outlines the fundamental concepts related to graphene and electronics, along with a description of various advanced and emerging applications of graphene-based bioelectronics. The book includes coverage of biosensors, energy storage devices such as biofuel cells, stretchable and flexible electronics, drug delivery systems, tissue engineering, and 3D printed graphene in bioelectronics. Taking an interdisciplinary approach, it explores the synergy produced due to charge transfer between biomolecules and graphene and will help the reader understand the promising bioelectronic applications of graphene-based devices. Graphene has applications in semiconductor electronics, replacing the use of traditional silicon-based devices due to its semi-metallic nature and tuneable energy band gap properties. The tuning of electron transfer with redox properties of biomolecules could potentially lead to the development of miniaturized bioelectronic devices. Thus, graphene, with its unique sensing characteristics, has emerged as an attractive material to produce biomolecular electronic devices. Cover Copyright Preface Graphene-Fundamentals Introduction History of graphene Graphene synthesis Top-down approach Mechanical exfoliation and cleavage Chemical exfoliation Bottom-up approach Epitaxial growth Chemical vapour deposition (CVD) Morphologies of graphene Electronic properties of graphene Graphene-biomolecular interactions Interactions in DNA-graphene hybrids Non-covalent interactions Covalent interactions Interactions in peptide-graphene hybrids Non-covalent interactions Covalent interactions Interactions in protein-graphene hybrids Non-covalent interactions Covalent interactions Interactions in carbohydrates-graphene hybrids Non-covalent interactions Covalent interactions Graphene-based hybrid biomaterials Graphene hybrids in tissue engineering Graphene hybrids in drug delivery Conclusions References Graphene-Based Transduction Systems in Biosensors Introduction Graphene-based transduction systems Electrochemical biosensors Piezoelectric biosensors Optical biosensors Conclusions References Graphene in Field Effect Transistor-Based Biosensors Introduction Graphene Bio-FET Substrate preparation Graphene selection Exfoliation and cleavage Chemically prepared graphene Chemical vapour deposition Placement of graphene on suitable substrates Exfoliated graphene Reduced graphene oxide Fabrication of FET sensors Non-covalent and covalent functionalization Non-covalent functionalization Covalent attachment Anti-biofouling Some graphene-based FET biosensors Genomic detection Biomarker detection Cellular detection Bio-FET-based label-free detection mechanism Indirect detection of macromolecules Direct detection of macromolecules Detection of oligonucleotides Detection of proteins Challenges of using graphene in fabrication of FET-based sensing devices Protocols for GFET device fabrications References Graphene-Based Biosensors for Detection of Protein and Nucleic Acid Introduction Graphene-based biosensors for nucleic acid detection Introduction Graphene-based aptamer biosensors Graphene-based DNA (deoxyribonucleic acid) biosensors Graphene-based PNA (peptide nucleic acid) biosensors Graphene-based biosensors for protein detection Introduction Graphene-based immunosensors Graphene-based enzyme biosensors Advanced applications of graphene-based biosensors Introduction Graphene-based biosensors in microfluidic chips Graphene-based biosensors for point-of-care diagnostics Graphene-based biosensors in integrated lab-on-a-chip Protocols Conclusions References Graphene-Based Wearable Biosensors Introduction Graphene-based flexible and stretchable materials Bio-integrated devices Wireless biosensors Applications of wearable biosensors Electrophysiological measurements Biomolecular detection Kinematic detection Challenges and future prospectus Conclusions References Graphene 3D Printing Introduction Direct 3D printing Direct ink writing for bioelectronic applications Direct bioprinting 3D freeze printing Digital light processing 3D printing Stereolithography Graphene nanofiller in stereolithographic printing Fused deposition technique Conclusions References Graphene-Based Microbial Fuel Cell Introduction Modified graphene as electrode material Synthesis of graphene used for electrode material MFC designing using graphene-based materials Graphene as an anode material Graphene as a cathode material MFC-based bioelectronic devices Conclusions References Graphene-Based Drug Delivery System Introduction Graphene-based drug delivery nano-vehicles Graphene interaction with cell membrane Impact of graphene on a human body Conclusions References Graphene in Tissue Engineeringand Electronics: Future Prospects and Challenges Introduction Fabrication of conductive scaffolds Chemical vapour deposition (CVD) 3D printing Electrospinning Freeze drying Free radical polymerization Self-assembly Direct vacuum filtration method Molecular interactions in biopolymers and graphene Graphene-SF hybrids Graphene-amyloid hybrids Graphene-chitosan hybrids Cellular behaviour on conductive scaffolds Neural regeneration Stem cell differentiation Scaffold as an electronic sensor Challenges Protocols Graphene-SF synthesis Graphene-chitosan synthesis References Commercial Prospects of Graphene-Based Biomolecular Electronic Devices and Challenges Introduction Graphene-based electronic devices Graphene-based biosensors Graphene-based biofuel cells Future challenges Conclusions References Index A B C D E F G H I L M N O P Q R S T U V W