Liquid biopsy in cancer patients : the hand lens for tumor evolution

Description

This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of "liquid biopsy" for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our "hand lens" to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists. Read more... Abstract: The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. Read more... Front Matter ....Pages i-xi Liquid Biopsy in Cancer Patients: The Hand Lens to Investigate Tumor Evolution (A. Russo, A. Giordano, C. Rolfo)....Pages 1-5 Precision Oncology: Present Status and Perspectives (Pierosandro Tagliaferri, Mariamena Arbitrio, Antonella Ierardi, Domenico Ciliberto, Maria Teresa Di Martino, Pierfrancesco Tassone)....Pages 7-26 Cancer Clonal Evolution and Intra-tumor Heterogeneity (Daniele Fanale, Juan Lucio Iovanna, Antonio Giordano, Christian Rolfo, Antonio Russo)....Pages 27-39 Tissue Versus Liquid Biopsy: Opposite or Complementary? (Walter Arancio, Beatrice Belmonte, Marta Castiglia, Arianna Di Napoli, Claudio Tripodo)....Pages 41-49 Technical Aspects for the Evaluation of Circulating Tumor Cells (CTCs) (A. B. Di Stefano, M. Castiglia, M. Ciaccio, Viviana Bazan)....Pages 51-54 Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs (M. Castiglia, A. Perez, M. J. Serrano, M. Ciaccio, V. Bazan, Antonio Russo)....Pages 55-60 Technical Aspects for the Evaluation of Exosomes and Their Content (Simona Fontana, Marco Giallombardo, Riccardo Alessandro)....Pages 61-70 Actionable Molecular Targets in Cancer Liquid Biopsy (Pierluigi Scalia, Stephen J. Williams, Antonio Russo, Antonio Giordano)....Pages 71-76 Liquid Biopsy in Breast Cancer (Lorena Incorvaia, Marta Castiglia, Alessandro Perez, Daniela Massihnia, Stefano Caruso, Sevilay Altintas et al.)....Pages 77-84 Liquid Biopsy in Gynecological Cancers (M. Castiglia, A. Listì, L. Incorvaia, V. Chiantera, Antonio Russo)....Pages 85-93 Liquid Biopsy in Prostate Cancer (A. Galvano, K. Papadimitriou, B. Di Stefano, M. Castiglia, Christian Rolfo)....Pages 95-102 Liquid Biopsy in Non-Small Cell Lung Cancer (NSCLC) (Christian Rolfo, Marta Castiglia, Alessandro Perez, Pablo Reclusa, Patrick Pauwels, Laure Sober et al.)....Pages 103-115 Liquid Biopsy in Colorectal Cancer (A. Galvano, M. Peeters, A. B. Di Stefano, M. Castiglia, Antonio Russo)....Pages 117-124 Diagnostic and Prognostic Performance of Liquid Biopsy in Hepatocellular Carcinoma (Ismail Labgaa, Amanda J. Craig, Augusto Villanueva)....Pages 125-135 Liquid Biopsy in Esophageal, Gastric, and Pancreatic Cancers (E. Giovannetti, D. Massihnia, N. Barraco, A. Listì, L. Incorvaia, M. Castiglia et al.)....Pages 137-150 Liquid Biopsy in Gastrointestinal Stromal Tumor (Daniele Fanale, Lorena Incorvaia, Marta Castiglia, Nadia Barraco, Giuseppe Badalamenti, Alex Le Cesne et al.)....Pages 151-159 Liquid Biopsies in Malignant Melanoma: From Bench to Bedside (Estíbaliz Alegre, Leyre Zubiri, Juan Pablo Fusco, Natalia Ramírez, Álvaro González, Ignacio Gil-Bazo)....Pages 161-193 Liquid Biopsies in Head and Neck Cancer Patients (Anthony H. Kong)....Pages 195-200 Clinical Practice Implications: Monitoring Drug Response and Resistance (Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone)....Pages 201-202 Erratum to: Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution (Antonio Russo, Antonio Giordano, Christian Rolfo)....Pages E1-E1 Back Matter ....Pages 203-214