ENGLISH

Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs

By Kyle John Wilby , Tony K. L. Kiang , Mary H. H. Ensom (eds.)

Book information

Publisher
ADIS
Year
2016
ISBN
978-981-10-2112-1, 978-981-10-2113-8
DOI
10.1007/978-981-10-2113-8
Language
english
Format
PDF
Filesize
2 MB (1929915 bytes)
Edition
1
Pages
VII, 135\136
Time added
2016-12-28 02:00:00
Pharmacology/Toxicology;Infectious Diseases

Description

Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.

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