ENGLISH

Endothelin and Its Inhibitors

By T. Masaki (auth.) , Timothy D. Warner Ph.D (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2001
ISBN
978-3-642-63237-2, 978-3-642-56899-2
DOI
10.1007/978-3-642-56899-2
Language
english
Format
PDF
Filesize
28 MB (29503566 bytes)
Series
Handbook of Experimental Pharmacology 152
Edition
1
Pages
560\548
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
general; Cell Biology; Internal MedicinePharmacology/Toxicology; Human Physiology; Biochem

Description

Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.

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