Molecular Basis and Emerging Strategies for Anti-aging Interventions

Description

This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences. Front Matter ....Pages i-xiv Aging Principles and Perspectives for Intervention (Suresh I. S. Rattan)....Pages 1-18 Non-coding RNAs as Potential Targets for Treatment and Early Diagnosis of Age-Associated Neurodegenerative Diseases ( Shamsuzzama, Lalit Kumar, Rizwanul Haque, Aamir Nazir)....Pages 19-33 The Potential Role of Stem Cell Reprogramming in Antiaging (Banu Orta Yilmaz, Melike Erkan)....Pages 35-45 Tissue Engineering and Regenerative Medicine: A Translational Research for Antiaging Strategy (Bhisham Narayan Singh, Anubha Joshi, Sarada Prasanna Mallick, Pradeep Srivastava)....Pages 47-66 Advances in Senotherapies (Janice Wong, Anam Qudrat, Abdullah Al Mosabbir, Kevin Truong)....Pages 67-82 Novel Classification Perspective of Geroprotective and Senolytic Drugs as an Antiaging Strategy (Karolin Yanar)....Pages 83-96 Antiaging Strategies Based on Telomerase Activity (Yasemin Aydin)....Pages 97-109 Immune Modulation and Its Role in Antiaging (Mustafa Erinc Sitar, Elcin Akduman Alasehir, Belkiz Ongen Ipek)....Pages 111-132 Sirtuin Modulators and Brain Aging (Hale Z. Toklu, Almari Ginory)....Pages 133-149 Inhibition of mTOR Signalling: A Potential Anti-aging Drug Strategy (Komal Saraswat, Raushan Kumar, Syed Ibrahim Rizvi)....Pages 151-160 Autophagy Induction: A Promising Antiaging Strategy (Abhishek Kumar Singh, Sandeep Singh, Syed Ibrahim Rizvi)....Pages 161-174 Computational Methods for Developing Novel Antiaging Interventions (Apramita Chand, Pragin Chettiyankandy, Maheswata Moharana, Satya Narayan Sahu, Sukanta Kumar Pradhan, Subrat Kumar Pattanayak et al.)....Pages 175-193 Intermittent Fasting-Dietary Restriction as a Geroprotector (Gurcharan Kaur, Taranjeet Kaur, Anuradha Sharma, Shaffi Manchanda, Harpal Singh, Shikha Kalotra et al.)....Pages 195-215 Melatonin and Its Antiaging Activity: New Approaches and Strategies for Age-Related Disorders (Sibel Suzen)....Pages 217-235 Antiaging and Neuroprotective Properties of Mediterranean Diet Components in Humans (Akhlaq A. Farooqui, Tahira Farooqui)....Pages 237-252 Epigenetic Changes in Aging and Modulation by Dietary Nutrients (Shambhoo Sharan Tripathi)....Pages 253-265 Role of Phytochemicals in Eliciting Longevity Genes (Kalaiselvi Periandavan, Prema Velusamy)....Pages 267-279 Antiaging Interventions: An Insight into Polyphenols and Brain Aging (S. Asha Devi, S. Raja Sekhar)....Pages 281-295 Activation of Plasma Membrane Redox System: A Novel Antiaging Strategy (Kanti Bhooshan Pandey, Syed Ibrahim Rizvi)....Pages 297-304 Impact of Sarcopenia in Healthy Aging and Suggested Interventions (Tuğba Erdoğan, Gülistan Bahat, Mehmet Akif Karan)....Pages 305-322 Antioxidants for Health and Longevity (Ramiah Sivakanesan)....Pages 323-341 Interventions to Prevent Premature Aging After Traumatic Brain Injury (Benjamin H. Murphy, Nicklas A. Sarantos, Alexandru Barabas, Robyn M. Hoelle, Tamara M. Vega)....Pages 343-353 Current Approaches of Anti-inflammatory-Dependent Antiaging Strategies (Hafize Uzun)....Pages 355-372 The Place of Geroprotective Agents in Life Quality and Longevity of Companion Animals (Alev Akdoğan Kaymaz)....Pages 373-386