ENGLISH

Gene Vaccines

By Richard Weiss , Viggo Van Tendeloo , Sandra Scheiblhofer , Josef Thalhamer (auth.) , Josef Thalhamer , Sandra Scheiblhofer (eds.)

Book information

Publisher
Springer-Verlag Wien
Year
2012
ISBN
3709104386, 9783709104385
DOI
10.1007/978-3-7091-0439-2
Google Books ID
vawPoRb_tNwC
Open Library ID
OL25189693M
Language
english
Format
PDF
Filesize
5 MB (4989111 bytes)
Edition
1
Pages
330\343
Orientation
yes
Scanned
no
Time added
2012-02-14 18:00:00
Vaccine; Immunology; Medical Biochemistry

Description

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

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