Cardiac Repolarization: Basic Science and Clinical Management

Description

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Physiology and Molecular Biology of Ion Channels Underlying Ventricular Repolarization of the Mammalian Heart (Thomas W. Comollo, Chuangeng Zhang, Xinle Zou, Robert S. Kass)....Pages 3-47 Neuromodulation of Cardiac Repolarization and Arrhythmogenesis (Fabrice Extramiana, Pierre Maison-Blanche)....Pages 49-76 Repolarization Remodeling in Structural Heart Disease (Andreas S. Barth, Gordon F. Tomaselli)....Pages 77-85 Cardiac Repolarization and Stem Cells: An Emerging Path Toward Precision Medicine (Massimiliano Gnecchi, Luca Sala, Peter J. Schwartz)....Pages 87-107 Role of Late Sodium Current During Repolarization and Its Pathophysiology (Mohamed Chahine)....Pages 109-117 Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis (Arja Suzanne Vink, Sally-Ann B. Clur, Pieter G. Postema, Nico A. Blom, Arthur A. M. Wilde)....Pages 119-129 ECG-Derived Evaluation of Cardiac Repolarization (Gioia Turitto, Nabil El-Sherif)....Pages 131-138 Front Matter ....Pages 139-139 Genotype-Phenotype Correlation in Congenital LQTS: Implications for Diagnosis and Risk Stratification (Ilan Goldenberg)....Pages 141-164 Clinical Management of LQTS Patients (Wojciech Zareba)....Pages 165-184 Drug-Induced Long QT Syndrome and Torsades de Pointes (Raymond L. Woosley, Peter J. Schwartz)....Pages 185-200 Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes (Nabil El-Sherif, Gioia Turitto, Mohamed Boutjdir)....Pages 201-216 Pathogenesis of Autoimmune-Associated Long QT Syndrome (Mohamed Boutjdir, Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Nabil El-Sherif)....Pages 217-226 The Role of Inflammation and Autoimmunity in Long QT Syndrome (Pietro Enea Lazzerini, Franco Laghi-Pasini, Nabil El-Sherif, Mohamed Boutjdir, Pier Leopoldo Capecchi)....Pages 227-251 Front Matter ....Pages 253-253 Genetics, Molecular Biology, and Emerging Concepts of Early Repolarization Syndrome (Charles Antzelevitch, Gregory Dendramis)....Pages 255-268 Electrocardiographic J Wave and Cardiovascular Risk in the General Population (Heikki V. Huikuri)....Pages 269-276 Benign Versus Malignant Early Repolarization Patterns (Raphael Rosso, Sami Viskin)....Pages 277-283 Genetic Architecture, Pathophysiology, and Clinical Management of Brugada Syndrome (John R. Giudicessi, Michael J. Ackerman)....Pages 285-299 Front Matter ....Pages 301-301 The Short QT Syndrome (Chiara Scrocco, Fiorenzo Gaita, Carla Giustetto)....Pages 303-311 Microvolt T-Wave Alternans: Pathophysiology and Clinical Aspects (Richard L. Verrier)....Pages 313-331 Action Potential Dynamics in Human Atrial Fibrillation (Junaid Ahmed Bakhtiyar Zaman, Sanjiv M. Narayan, Michael R. Franz)....Pages 333-345 Back Matter ....Pages 347-354