ENGLISH

Leucine-Rich Repeat Kinase 2 (LRRK2)

By Hardy J. Rideout (eds.)

Book information

Publisher
Springer International Publishing
Year
2017
ISBN
978-3-319-49967-3, 978-3-319-49969-7
DOI
10.1007/978-3-319-49969-7
Language
english
Format
PDF
Filesize
5 MB (5259605 bytes)
Series
Advances in Neurobiology 14
Edition
1
Pages
XVII, 271\280
Time added
2017-06-25 01:07:36
Neurosciences;Neurology

Description

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

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