Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

Description

Clinical relevance....Pages 3-20 Renal handling of drugs and xenobiotics....Pages 21-46 Pharmacovigilance....Pages 47-50 Immunologically-mediated toxin-induced renal disease....Pages 51-64 Cellular mechanisms of nephrotoxicity....Pages 65-76 Animal models for the assessment of acute renal dysfunction and injury....Pages 77-114 Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms....Pages 115-147 Aminoglycosides and vancomycin....Pages 151-170 Beta-lactam antibiotics....Pages 171-198 Amphotericin B....Pages 199-222 Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones....Pages 223-247 Antiviral agents....Pages 249-262 Analgesics and 5-aminosalicylic acid....Pages 263-278 Non-steroidal anti-inflammatory drugs....Pages 279-306 Gold salts, D-penicillamine and allopurinol....Pages 307-324 Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists....Pages 325-338 Diuretics....Pages 339-351 Anticancer drugs....Pages 353-372 Anesthetic agents....Pages 373-381 Illicit drug abuse....Pages 383-402 Calcineurin inhibitors and sirolimus....Pages 403-458 Immunomodulators: interleukins, interferons, and the OKT3 monoclonal antibody....Pages 459-482 Radiocontrast agents....Pages 483-494 Lead nephropathy....Pages 495-506 Cadmium-induced renal effects....Pages 507-530 Mercury-induced renal effects....Pages 531-544 Hydrocarbons, silicon-containing compounds and pesticides....Pages 545-558 Lithium-induced renal effects....Pages 559-578 Aristolochic acid nephropathy after Chinese herbal remedies....Pages 579-586 Balkan endemic nephropathy....Pages 587-601 Nephrotoxins in Africa....Pages 603-610 Paraphenylene diamine hair dye poisoning....Pages 611-618 Urinary biomarkers and nephrotoxicity....Pages 621-655 Pharmacological aspects of nephrotoxicity....Pages 657-666 Drug dosage in renal failure....Pages 667-679