Basic Science of PET Imaging

Description

This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields. Front Matter....Pages i-xix Front Matter....Pages 1-1 Basic Radiation Physics....Pages 3-35 Radiation Safety and CT Dosimetry in PET/CT Imaging....Pages 37-64 Radiation Dosimetry of PET Imaging....Pages 65-76 Front Matter....Pages 77-77 Chemistry of PET Radiopharmaceuticals: Labelling Strategies....Pages 79-103 Quality Control of PET Radiopharmaceuticals....Pages 105-126 Regulation of PET Radiopharmaceuticals Production in Europe....Pages 127-143 Regulatory Aspects of PET Radiopharmaceutical Production in the United States....Pages 145-170 Front Matter....Pages 171-171 PET Physics and Instrumentation....Pages 173-197 PET/MR: Basics and New Developments....Pages 199-228 PET Calibration, Acceptance Testing, and Quality Control....Pages 229-255 Front Matter....Pages 257-257 PET Image Reconstruction: Methodology and Quantitative Accuracy....Pages 259-284 Image Processing and Analysis of PET and Hybrid PET Imaging....Pages 285-301 Basics and Advances of Quantitative PET Imaging....Pages 303-322 Compartmental Modeling in PET Kinetics....Pages 323-352 Front Matter....Pages 353-353 Partial Volume Correction in PET Imaging....Pages 355-378 Motion Artifacts and Correction Techniques in PET/CT....Pages 379-396 Front Matter....Pages 397-397 Physiologic and Molecular Basis of PET in Cancer Imaging....Pages 399-427 Clinical Applications of PET/CT in Oncology....Pages 429-450 Cardiac PET Imaging: Principles and New Developments....Pages 451-483 PET in Neurological and Psychiatric Disorders: Technologic Advances and Clinical Applications....Pages 485-535 Front Matter....Pages 397-397 Role of PET/CT in Pediatric Malignancy....Pages 537-575 Role of PET/CT in Radiotherapy Treatment Planning....Pages 577-608 Back Matter....Pages 609-619