Molecular and Cellular Biology of Neuroprotection in the CNS

Description

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Excitatory Amino Acid Neurotoxicity....Pages 3-40 Neuronal Survival and Cell Death Signaling Pathways....Pages 41-86 Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System....Pages 87-113 Cellular and Molecular Determinants of Glial Scar Formation....Pages 115-158 Front Matter....Pages 159-159 Na + Channels and Ca 2+ Channels of the Cell Membrane as Targets of Neuroprotective Substances....Pages 161-181 Intracellular Ca 2+ Handling....Pages 183-196 Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands....Pages 197-223 A Role for Glutamate Transporters in Neurodegenerative Diseases....Pages 225-248 Purines and Neuroprotection....Pages 249-280 Heat Shock Proteins and Neuroprotection....Pages 281-299 Front Matter....Pages 301-301 Neurotrophins....Pages 303-334 Fibroblast Growth Factors and Neuroprotection....Pages 335-351 TGF-ßS and Their Roles in the Regulation of Neuron Survival....Pages 353-374 Vascular Endothelial Growth Factor....Pages 375-394 Front Matter....Pages 395-395 Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins....Pages 397-430 Invasive Drug Delivery....Pages 431-451 Front Matter....Pages 453-453 Ischemia and Stroke....Pages 455-473 Neuroprotective Strategies in Alzheimer’s Disease....Pages 475-496 Back Matter....Pages 497-501