Metabolic Interaction in Infection

Description

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Cellular Metabolism at a Glance (Inês Mesquita, Fernando Rodrigues)....Pages 3-27 Interaction Between Nutrition and Metabolism (Stella Maria Barrouin-Melo, Yadira Alejandra Morejón Terán, Johanna Anturaniemi, Anna Katrina Hielm-Björkman)....Pages 29-114 Interplay Between Metabolic Sensors and Immune Cell Signaling (Prashant Chauhan, Arup Sarkar, Bhaskar Saha)....Pages 115-196 Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis (Inês Mesquita, Baptiste Vergnes, Ricardo Silvestre)....Pages 197-220 Mitochondrial Bioenergetics and Dynamics During Infection (Cynthia Soultawi, Yasmina Fortier, Calaiselvy Soundaramourty, Jérôme Estaquier, Mireille Laforge)....Pages 221-233 Computational Systems Biology of Metabolism in Infection (Müberra Fatma Cesur, Ecehan Abdik, Ünzile Güven-Gülhan, Saliha Durmuş, Tunahan Çakır)....Pages 235-282 Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression (Miguel Fernández-García, David Rojo, Fernanda Rey-Stolle, Antonia García, Coral Barbas)....Pages 283-315 Front Matter ....Pages 317-317 Metabolic Host Response to Intracellular Infections (Catarina M. Ferreira, Ana Margarida Barbosa, Inês M. Pereira, Egídio Torrado)....Pages 319-350 Protozoan Parasite Auxotrophies and Metabolic Dependencies (Elodie Gazanion, Baptiste Vergnes)....Pages 351-375 Viral Manipulation of the Host Metabolic Network (Inês Mesquita, Jérôme Estaquier)....Pages 377-401 Metabolic Regulation of Innate Immunity to Fungal Infection (Cláudia S. Rodrigues, Cláudia F. Campos, Cristina Cunha, Agostinho Carvalho)....Pages 403-420 Metabolic Crosstalk Between Host and Parasitic Pathogens (Diana Moreira, Jérôme Estaquier, Anabela Cordeiro-da-Silva, Ricardo Silvestre)....Pages 421-458 Microbiome and Gut Dysbiosis (José E. Belizário, Joel Faintuch)....Pages 459-476